Intimal hyperplasia thickness and blood flow in an axis-deviated arterial bypass

作     者：Zaipin Xu~1,Wei Zhao~1,Anqiang Sun~2,Xiaoyan Deng~2,Yubo Fan~2,Qingyu Wang~1, Dingkun Wang~1,Junbo Gao~1,Peng Luo~1,Yao Peng~1,Yuhuan Lv~1,Zhe Ma~1,Ke Wang~3 (1.Department of Veterinary medicine,College of Animal Science,Guizhou University, Guiyang 550025,China 2.Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University,Beijing 100191,China 3.The First Affiliation Hospital,Dalian Medical University,Dalian 116011,China) 

会议名称：《中国畜牧兽医学会2010年学术年会——第二届中国兽医临床大会》

会议日期：2010年

学科分类：090603[农学-临床兽医学] 09[农学] 0906[农学-兽医学] 

关 键 词：Axis-deviated arterial bypass Bypass surgery Intimal hyperplasia Computational fluid dynamics Swirling flow Canine 

摘      要：Extensive work has shown that slow recirculation flow zone with low wall shear stress and high oscillatory shear index occurred in a bypassed artery is an important factor for the development of intimal hyperplasia(IH) in the distal *** substantiate our hypothesis that intentionally inducing swirling flow in a bypassed artery can suppress IH development along the floor of the host artery,we constructed an axis-deviated arterial bypass(ADAB) on canine common carotid artery in which swirling flow was created in the host artery and compared it with a conventional arterial bypass(CAB) in terms of IH development along the host artery *** flows in the two bypass models were characterized *** animal experiment showed that intimal thickness was 110.50±9.62μm in the CAB group and 60.32±3.52μm in the ADAB group, *** blood flow simulation revealed that the flow structure in the host artery of the ADAB model was in the form of swirling flow that was very different from the vortex flow in the conventional model,which characterized with flow stagnation and low wall shear stress along the host artery *** swirling flow created by the axis-deviated bypass eliminated the stagnation flow and enhanced wall shear stress,hence suppressed IH development along the host artery ***,the present study has pointed out a new way to eliminate and/or suppress the slow recirculation flow zones in bypassed arteries.