Attenuated mesangial cell proliferation related to store-operated Ca2+ entry in aged rat:the role of STIM 1 and Orail

作     者：Bing Shen~(1*),Jin-hang Zhu~1,Jin Zhang~1,Zhao-yi Wang~1,Fei-fei Jiang~1,Yang Zhang~2, Dao-ping Ke~1,Rong Ma~3,Juan Du~(1*) 1 Department of Physiology,Anhui Medical University,2 Anhui Provincial Hospital. Comprehensive Surgery,Hefei 230032,China 3 Department of Integrative Physiology,University of North Texas Health Science Center at Fort Worth,Fort Worth,Texas. 

会议名称：《第九届全国钙信号和细胞功能研讨会》

会议日期：2012年

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

关 键 词：Aged Store-operated Ca2+entry,STIM 1 Orai 1 glomerular mesangial cell. 

摘      要：Store-operated Caentry(SOCE)is one common and ubiquitous mechanism of regulating Cainflux into cells and participates in numerous biological processes including cell *** mesangial cells have the crucial function controlling glomerular filtration *** clinical point of view,plenty of physiological functions will change with *** the present study,we used a Ca pump inhibitor thapsigargin to deplete Ca store and activate SOCE and found that SOCE was significantly attenuated in glomerular mesangial cells from aged(22 months) *** expression levels of SOCE-related components,STIM 1 and Orai 1 in fresh isolated