Two Concise Methods to Prepare Peptide-oligonucleotide Conjugates
会议名称：《第五届全国化学生物学学术会议》
会议日期：2007年
学科分类：0710[理学-生物学] 07[理学] 08[工学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种]
基 金：This work was supported by the National Natural Science Foundation of China(No.20332010)
关 键 词：RNA interference peptide-oligonucleotide conjugates
摘 要：正RNA interference（RNAi）has been rapid progress towards its application as one of the most important molecular in molecular *** order to enhance siRNA’s stability,cell uptaken and gene silence effect,we designed and synthesized peptide-siRNA conjugates using phosphodiester bond to covalently link the peptide