Palladium-Catalyzed Dearomatizing Coupling of Aryl Halides with Furfural Tosylhydrazones:A Novel Access to Polysubstituted and Functionalized Indoles and Thiophenes
作者单位：School of Chemistry and Chemical EngineeringSouth China University of Technology
会议名称：《中国化学会全国第十二届有机合成化学学术研讨会》
会议日期：2015年
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金：supported by the National Natural Science Foundation of China(No.21272078)
关 键 词：furfural tosylhydrazones indole thiophene dearomatization
摘 要：The indole and thiophene structure is probably the heterocyclic nucleus that concentrates the most interest because of its presence in a plethora of natural products and molecules with biological activity. Although nowadays there are a large number of methodologies for the synthesis and structural modification of the indole scaffold, the development of alternative approaches that may allow for the straightforward preparation of structurally diverse indoles and thiophene is a field of constant *** a continuous interest in the developing new synthetic methods for the dearomatization of furan ring and using sustainable furan derivative as the starting materials in organic synthesis,Herein,we’d like to report the palladium-catalyzed dearomatizing coupling of aryl halides with furfural tosylhydrazones involving dearomatization of furan ring,which led to the novel synthesis of polysubstituted and functionalized indoles and thiophenes.