Production of type Ⅰ interferon by circulating monocyte-like cells with deficient production by plasmacytoid dendritic cells in SLE
作者单位：Division of Rheumatology and Clinical ImmunologyUniversity of FloridaPO Box 100221GainesvilleFL 32610-0221USA Division of Rheumatology and Clinical ImmunologyUniversity of FloridaPO Box 100221GainesvilleFL 32610-0221USA Division of Rheumatology and Clinical ImmunologyUniversity of FloridaPO Box 100221GainesvilleFL 32610-0221USA Division of Rheumatology and Clinical ImmunologyUniversity of FloridaPO Box 100221GainesvilleFL 32610-0221USA Division of Rheumatology and Clinical ImmunologyUniversity of FloridaPO Box 100221GainesvilleFL 32610-0221USA Division of Rheumatology and Clinical ImmunologyUniversity of FloridaPO Box 100221GainesvilleFL 32610-0221USA Division of Rheumatology and Clinical ImmunologyUniversity of FloridaPO Box 100221GainesvilleFL 32610-0221USA
会议名称：《The 8th International Congress on SLE》
会议日期：2007年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
摘 要：正Purpose:We have shown that in SLE,increased expression of Type I interferon（IFN-I）inducible gene Mxl is associated with anti-dsDNA and anti-Sm/RNP antibodies. Plasmacytoid dendritic cells（PDCs）make high levels of IFN-I in response to viral infection and also are thought to be the major source of ***,the number of