Copper-Catalyzed Annulation of Isothiocyanates with Diaryliodonium Salts: Arylation–Cyclization Approach to Quinolines
作者单位：College of Chemistry and Molecular EngineeringQingdao University of Science and Technology
会议名称：《中国化学会全国第十二届有机合成化学学术研讨会》
会议日期：2015年
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金：国家自然基金(No.21572110) 山东省自然基金(No.ZR2014BM006)资助项目
关 键 词：quinolines isothiocyanate diaryliodonium salts
摘 要：Quinolines are privileged scaffolds in various bioactive natural products and pharmaceuticals.1 Therefore,many methods for the synthesis of quinolines have been developed including Combes quinoline synthesis,Friedlander synthesis,Skraup synthesis and so *** on our previous studies on the diaryliodonium salts,we herein reported a novel copper-catalyze tandem arylation-cyclization process for the preparation of quinolines from readily available isothiocyanates with diaryliodonium salts.