Membrane depolarization activates the mitochondrial protease OMA1 By stimulating Self-cleavage
作者单位:College of Life Sciences Wuhan University
会议名称:《中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议》
会议日期:2014年
学科分类:0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种]
摘 要:Mitochondrial inner membrane fusion depends on the dynamin-related GTPase OPA1 and the function of OPA1is regulated by proteolytic *** mitochondrial proteases Yme1L and OMA1 cleave OPA1 at S2 and S1sites,***,we show that OMA1 is cleaved to a short form(S-OMA1)by itself upon mitochondrial