Changes of TXA2 and PGI2 content and anticoagulative and fibrinolytic activity in the plasma in a rat model of topical FeCl3-induced carotid artery thrombosis
会议名称：《湖南省生理科学会2006年度学术年会》
会议日期：2007年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：教育部科学研究重点项目(204100) 湖南省教育厅重点项目(03A033)
摘 要：Aim To investigate changes of TXA and PGI content and anticoagulative and fibrinolytic activity in the plasma in a rat model of topical FeCl-induced carotid artery *** Thrombi were induced by topical ferric chloride to left carotid artery in *** content of TXB and PGI(stabile metabolite of TXA and PGI),activity of t-PA,PAI-1,PLG,AT-Ⅲand PC in the plasma in the model of thrombosis were *** Occlusive thrombi were induced by applying FeCl(2.16 mol·L) to left carotid *** content of TXB was increased markedly (P0.05),t-PA/PAI-1 ratio reduced(PP0.05). Ticlopidine could inhibit thrombosis induced by ferric chloride,but it did not influence TXB and 6-keto-PGFαcontent and activity of AT-Ⅲand PC in the *** could enhance activity of t-PA in the plasma, it may be related to decrease of t-PA consumption by inhibiting thrombosis. Antithrombosis action of ticlopidine may not be concerned to inhibiting production of TXB of *** could inhibit thrombosis also,but it did not influence TXB and 6-keto-PGFαcontent in the *** could enhance activity of t-PA and t-PA/PAI-1 ratio,which may be related to promoting release of t-PA in vascular endothelial *** could reduce activity of AT-Ⅲ,which may be concerned with combination of LMWH and AT-Ⅲresult in AT-Ⅲ*** Ferric chloride may induce occlusive thrombosis in *** may be associated with activation of platelet and blood coagulation system,lower of anticoagulative protein and fibrinolytic activity.