Evidence for lentivirus capsid protein interaction with dynein motors:Insights to drug design targeting viral retrograde transport

作     者：Yang Su,Wentao Qiao,Yunqi Geng,Jun zhou,Qimin Chen Key Laboratory of Molecular Microbiology and Biotechnology(Ministry of Education) and Key Laboratory of Microbial Functional Genomics(Tianjin),College of Life Sciences,Nankai University,Tianjin 300071,China 

会议名称：《第十一届中国细胞生物学学术大会暨2009西安细胞生物学国际会议》

会议日期：2009年

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

关 键 词：dynein capsid protein bovine immunodeficiency virus 

摘      要：Intracellular virus particles embezzle the host transport system to translocate the cytoplasm. Cytoplasmic dynein as well as the dynactin complex are microtubule-associated motors and responsible for virus motion through cell periphery to perinuclear viral replication site. Lentiviruses,such as noted human immunodeficiency virus(HIV),travel along the microtubule