A HIV-1 envelope immunogen with W427S mutation in CD4 binding site induced more T follicular helper memory cells and reduced non-specific antibody responses
作者单位：Department of MicrobiologyHarbin Medical University
会议名称：《第九届全国免疫学学术大会》
会议日期：2014年
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学]
摘 要：The CD4 binding site(CD4BS)of the HIV-1 envelope glycoprotein(Env)contains epitopes for broadly neutralizing antibody(nAb)and is the target for the vaccine ***,the CD4BS core containing residues 425-430overlaps the B cell superantigen site and may be related to B cell exhaustion in HIV-1 ***,production