A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers

作     者：Tong Sun~(1,4), Yang Gao~(2,4), Wen Tan~1, Sufang Ma~2, Yuankai Shi~3, Jiarui Yao~3, Yongli Guo~1, Ming Yang~1, Xuemei Zhang~1, Qingrun Zhang~2, Changqing Zeng~2 & Dongxin Lin~1 1 Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, Chiea. 2 Beijing Genomics Institute, Chinese Academy of Sciences, Beijing, China, 3 Department of Medical Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. 4 These authors contributed equally to this work. Correspondence should be addressed to D.L. 

会议名称：《全国肿瘤流行病学和肿瘤病因学学术会议》

会议日期：2015年

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

摘      要：正Caspases are important in the life and death of immune cells and therefore influence immune surveillance of malignancies. We tested whether genetic variants in CASPS, CASP10 and CFLAR, three genes important for death receptor-induced cell killing residing in tandem order on chromosome 2q33, are associated with cancer susceptibility. Using a haplotype-tagging SNP approach, we identified a six-nucleotide deletion （-652 6N del） variant in the CASP8 promoter associated with decreased risk of lung cancer. The deletion destroys a stimulatory protein 1 binding site and decreases CASP8 transcription. Biochemical analyses showed that T lymphocytes with the deletion variant had lower caspase-8 activity and activation-induced cell death upon stimulation with cancer cell antigens. Case-control analyses of 4,995 individuals with cancer and 4,972 controls in a Chinese population showed that this genetic variant is associated with reduced susceptibility to multiple cancers, including long, esophageal, gastric, colorectal, cervical and breast cancers, acting in an allele dose-dependent manner. These resulls support the hypothesis that genetic variants influencing immune status modify cancer susceptibility.