Carbonyl Reductase 1 as a Novel Target of (-)-epigallocatechin gallate against hepatocellular carcinoma
作者单位：Fudan University
会议名称：《中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议》
会议日期：2010年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
摘 要：Human carbonyl reductase 1(CBR1) converts the antitumor drug and anthracycline daunorubicin(DNR) into the alcohol metabolite daunorubicinol(DNROL) with significantly reduced antitumor activity and cardiotoxicity,and this limits the clinical use of *** of CBRl can thus increase the efficacy and decrease the toxicity of *** we report that(-)-epigallocatechin gallate(EGCG) from green tea is a promising inhibitor of *** directly