Interaction between Polymorphism of rs708272 on CETP and Environmental Factors are Associated with Low HDL-C Levels in Chinese
作者单位：Shenzhen center for chronic disease control Department of Nutrition and food hygiene Huazhonguniversity of science and technology
会议名称：《第十七届中国科协年会——分12 新时代下大营养观专题论坛》
会议日期：2015年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：funded by the National Natural Science Foundation of China(No.81102127) Science project of Shenzhen(No.201202103) National Key Technology Research and Development Program of China(2012BAI02B02)
关 键 词：high-density lipoprotein cholesterol single nucleotide polymorphisms Chinese
摘 要：Conflict results were reported about the association between multiple single nucleotide polymorphisms(SNPs) and low plasma high-density lipoprotein cholesterol(HDL-C) level in different populations. We conducted this study to find these potential associations in Chinese. Method: Twelve candidate SNPs in HDL-C metabolic genes were genotyped by PCR-RFLP method in 3809 Shenzhen citizens from a cross-sectional study. Plasma HDL-associated lipoproteins, enzymes and lipid parameters of each subject were also tested. Results:The genotype AA in rs708272 of cholesteryl ester transfer protein(CETP) intron was associated with low HDL-C level in Chinese(ORadj=0.78 for AA vs. GG, P0.05) and the HDL-C level of homozygous mutation carriers was significantly higher than that of homozygous wild-type carriers(1.28±0.31mmol/L vs. 1.20±0.16mmol/L). Multifactor dimensionality reduction analysis found that the male subjects with non-alcohol consumes, smoke and contained genotype GG in rs708272 was subjects with highest risk for abnormally reduced HDL-C level(OR=7.32, P=0.012, compared with contrary subjects).Conclusion:Homozygous mutant of rs708272 was associated with low HDL-C level in Chinese. Gene-environmental interaction was found between rs708272, sex, smoking and alcohol consumption, and associated with low HDL-C level.