PIFA-Mediated intermolecular C-N Bond Cleavage/C-N Bond Formation Reaction: Synthesis of Amides
作者单位：Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine ChemicalsKey Laboratory of Green Chemical Media and Reactions Ministry of Education School of Chemistry and Chemical Engineering Henan Normal University
会议名称：《河南省化学会2016年学术年会》
会议日期：2016年
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
关 键 词：Hypervalent iodine reagents Amides Hydrazides PIFA
摘 要：Amides are one of the most ubiquitous and important functional groups in natural products and synthetic drugs. The research of forming methods for amide is of great significance. And also it is now a hotspot in the research of the synthetic method. Hypervalent iodine reagents due to its ready availability, low toxicity, easy handling, and reactivity similar to that of heavy metal reagents were used to the N-N, S-N or C-C bond formation, and provide a new strategy for organic ***, we describe a new method to synthesize varieties of functionalized amides in the presence of PIFA in moderate to good yields starting from hydrazides and nitriles.