Analyzing the optokinetic responses for detecting the effects of anxiolytic drugs on zebrafish larvae’s visual system
会议名称：《中国神经科学学会第九届全国学术会议暨第五次会员代表大会》
会议日期：2011年
学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学]
关 键 词：OKR anxiolytic drugs visual system
摘 要：正Optokinetic response（OKR） is a reflexive response which is elicited by a slowly moving image across the retina.The stimulation is generated by a drum with black-white vertical stripes on its internal wall horizontally rotating around the larvae.We treat 8-9 dpf larvae by either egg water or drugs for an hour before the experiments.The larvae are then transferred to a 3.5 cm-diameter petri dish containing 6%methylcellulose at the center of the drum.Images of the optokinetic responses are captured by CCD camera and processed by Image-J to analyze the effects of anxiolytic drugs on visual system.