Cilostazol,a phosphodiesterase 3 inhibitor,protects mice against acute and late ischemic brain injuries

作     者：Ye Yi-Lu Shi Wen-Zhen Zhang Wei - Ping Wang Meng - Ling Zhou Yu Fang San - Hua Liu Li - Ying Zhang Qi Yu Yue - Ping Wei Er - Qing Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058 Department of Pharmacology, Zhejiang Medical College, Hangzhou 310053, China 

会议名称：《第十二届全国神经精神药理学学术交流会》

会议日期：2006年

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

摘      要：Cilostazol, a selective inhibitor of phosphodiesterase 3 , exerts neuroprotective effects on acute brain injury after cerebral ischemia in rats. However, it is unknown whether cilostazol affects the subacute or chronic ischemic injury. In the present study, we evaluated the dose - and time - dependent effect of cilostazol on acute ischernic brain injury and the long - lasting effect on the late ( subacute/chronic) injury in mice with focal cerebral ischemia. We found that pre -treatment of cilostazol (injected i. p. at 30 min before ischemia) significantly ameliorated the acute injury 24 h after ischemia, and the effective doses were 3-10 mg/kg. The post - treatment of cilostazol (10 mg/kg) was effective on the