Preparation and Biodistribution of Tyrosine Modified Multiwall Carbon Nanotubes

作     者：LIANG Geyu 1, ZHANG Tao 2, LIU Ran 1, YE Bing 1, YIN Lihong 1, PU Yuepu 1* (1. School of Public Health, Southeast University, Nanjing 210009 2. Department of Material Science and Engineering, National Key Laboratory of Solid State Microstructures, Nanjing University, Nanjing 210093) 

会议名称：《第十届中国科协年会》

会议日期：2008年

学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学] 

基　　金：973 Program of the Ministry of Science and Technology of China (No. 2006CB705602) 

关 键 词：Carbon nanotubes (CNTs) Tyrosine 125I labeled Biodistribution 

摘      要：The functionalized derivative outside carbon nanotubes (CNTs) is likely to improve their biocompatibility. Therefore, CNTs have attracted great attention not only in electrical, optical and mechanical applications but also in biological and pharmaceutical applications. Thus, it is important to examine the biodistribution and kinetics of the carbon-based nanotubes when they are introduced into living systems. Here, we synthesized and characterized tyrosine functionalized carbon nanotubes (CNTs-Tyr) and show the biodistribution profiles of CNTs-Tyr in mice following three different administrations by 125I labeled radioisotope tracing method. It is shown that the behavior of CNTs-Tyr in mice is different from that reported previously. CNTs-Tyr was quickly delivered around the whole mice body and accumulated mainly in lung and also slightly in spleen and liver after mice were exposed by intravenous injection for 24hrs. The functionalized group of carbon nanotubes may have effect their affinity to organs. The results provide basic biological information for the biomedical application and risk assessment of CNTs.