Novel proteomics method reveals an atypical hyperacidic Grp78/Bip isoform upregulated by treatment with TLR2 agonists or bacterial infection in THP-1 cells without endoplasmic reticulum stress and apoptosis
作者单位：Molecular Biology Research CenterSchool of Biological Science and TechnologyCentral South University
会议名称：《中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议》
会议日期：2010年
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学]
摘 要：TLRs are pattern recognition receptors that act as primary sensors of microbial *** are now 10 TLRs identified in humans,found in both the innate and the adaptive immune system,where they play a pivotal role in the response directed against distinct,structurally conserved components of ***-1 macrophage-like cells were infected with Mycobacterium avium,Borrelia burgdorferi or heat-killed ***,or treated with agonists of TLR2 and TLR4 for different *** screened for proteome differences induced by the different agents by comparing with untreated cells after protein *** of the up-regulated phosphorylated proteins after infection or treatment with TLR2 agonists was identified as a novel