1-alpha,25-dihydroxyvitamin D3 combined with co-stimulatory molecules blockade prolongs survival of cardiac allografts in alloantigen-primed mice

作     者：Shuangyue Xu1,Guoliang Yan1,2,Yingying Lin1,Yuan Wu1,YejianBin2,Zhongquan Qi1,2 1.Organ Transplantation Institute of Xiamen University 2.Medical College,Xiamen University 

会议名称：《2012中国器官移植大会》

会议日期：2012年

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

摘      要：Memory T cells present a unique challenge in *** memory T cells express robust immune responses to defend the invading pathogens,they may be resistant to the effects of immunosuppressive therapies used to prolong graft survival. In previous studies,it was found that 1-alpha,25-dihydroxyvitamin D3(1,25(OH)D) could reduce acute cardiac allograft rejection in ***,we further investigated that the effect of 1,25(OH)D could obviously reduce the proliferation of splenic T cells in alloantigen-primed mice in ***,we evaluated l,25(OH)D treatment alone or in combination with