Pamidronate and Clodronate Inhibit Insulin-like Growth Factor-1(IGF-I)-Induced HIF-1α Protein Accumulation and VEGF Expression in Human Breast Cancer Cells
作者单位：Center for Craniofacial Molecular BiologyUniversity of Southern CaliforniaSchool of DentistryLos AngelesCalifornia 90033 广东医学院生物化学与分子生物学教研室湛江 524023
会议名称：《中国细胞生物学学会第九次会员代表大会暨青年学术大会》
会议日期：2007年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
关 键 词：pamidronate clodronate IGF-I HIF-1α VEGF
摘 要：Pamidronate and clodronate,the secondary-generation bisphosphonates (BPs),have been found to have antiangiogenic activities.A growing body of evidence has demonstrated that hypoxia-inducible factor (HIF)-1α and vascular endothelial growth factor(VEGF)play a pivotal role in tumor *** this study,we investigated