Viral and inflammatory factors determine the occurrence of hepatitis B virus-related hepatocellular carcinoma
会议名称：《全国肿瘤流行病学和肿瘤病因学学术会议》
会议日期：2015年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：National Natural Science Foundation of China(81025015 30921006)
摘 要：Primary liver cancer in men is the second most frequent cause of cancer death and hepatocellular carcinoma(HCC) accounts for 70%to 85%of the total liver cancer burden *** infection with hepatitis B virus(HBV) contributes to more than three quarters of all HCC cases *** serum viral load(≥10 copies/mL) is the most reliable indicator of viral replication in predicating the development of *** genotype C(C2) can predict HCC in the HBV-infected subjects,especially in the cirrhotic patients over 50 years,whereas genotype B(B2) is associated with the development of HCC in the non-cirrhotic young patients and relapse of HCC after surgical *** HBV subgenotype has distinct pattern of *** mutations including C1653T, T1753V,A1762T/G1764A,T1674C/G,C1766T,T1768A,G1899A,C2002T, A2159G,A2189C,G2203A/T,T53C,preS2 start codon mutation,preS1 deletion, C2964A,A2962G,C3116T,and C7A are clearly associated with an increased risk of *** mutations in combinations are specifically associated with *** mutations accumulate during the progression of chronic HBV infection and can predict the occurrence of *** inflammation,possibly initiated by HBV and maintained by imbalance either between Th1 and Th2 cells or between Th17 and Treg cells,may lead to an increase in the frequency of viral mutation via induction of cellular cytidine *** HBV mutations may be selected by immune reaction,whereas the escaped HBV mutants might in turn play an active role in *** inflammatory pathways including nuclear factor-κB, the signal transducer and activator of transcription 3,Wnt/β-catenin,and transforming growth factor-β1 signaling pathways contribute,at least partially,to the inflammation-necrosis- regeneration process,ultimately *** hallmark molecules including serum IL-6 can predict the occurrence of this malignancy in the hepatitis B *** factors are of importance for developing active