Serologic Survey of the Pandemic H1N1 2009 Virus in Guangdong province,China:a cross sectional study
作者单位：Center for Disease Control and Prevention of Guangdong Province
会议名称：《2011广东省预防医学会学术年会》
会议日期：2011年
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学]
摘 要：Background:Relying on surveillance of clinical cases limits the ability to understand the full impact and severity of an epidemic,which urges a deep insight into the serological evidence of infection and transmission feature of pandemic H1N1 2009(pH1N1) virus in Guangdong province. Methods:In this cross-sectional serological survey,serum samples were collected by multi-stage stratified random sampling in Jan *** titers were measured by hemagglutination inhibition(HI) ***-specific and region-specific prevalence were calculated based on the results of HI assay(positive,HI titer≥1:40). Results:A total of 4,319 serum samples had been collected from subjects without vaccination with pH1N1 *** seroprevalence was 22.82%(985/4,319).By contrast,there was a marked spatial heterogeneity in *** seroprevalence was 27.3%in large city,21.4% in medium cities,higher than that of 20.2%in rural *** seroprevalence was highest in 11-20 age group(32.8%),however,in those above 60 years of age group,which was 12.6%, lower than other age *** the other hand,antibody titers to pH1N1 virus were highest in school children,which were followed by a gradual decrease in ***,in the elderly groups from cities,especially from large city,the antibody titer to pH1N1 increased significantly and reached a much higher level. Conclusion:Our results showed that the prevalence for pH1N1 was correlated with age and population *** antibody may have protected the very old from pH1NI infection,while original antigenic sin and immunosenescence may have contributed to greater severity once *** should be considered when studying the pathogenesis and transmission of influenza virus and formulating strategies on vaccination and treatment.