Clinical ef cacy and safety of Chinese herbal medicine for Wilson's disease:A systematic review of 9 randomized controlled trials
会议名称：《2012中国医师协会中西医结合医师分会神经病学专家委员会学术年会》
会议日期：2012年
学科分类：1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
关 键 词：Wilson’s disease Chinese herbal medicine Systematic review
摘 要：Wilson’ s disease is an autosomal recessive disorder of copper *** being treatable,there is no universally accepted treatment ***,various Chinese herbal medicines(CHMs)are widely used in the treatment of Wilson’s disease in China,but there is a lack of reliable scienti c evidence for the effectiveness of such *** objective of this systematic review is to assess the clinical ef cacy and safety of CHM as an alternative or/and adjuvant therapy for Wilson’ s disease.A systematic literature search in different medical databases was performed to identify randomized controlled trials comparing CHM as monotherapy or CHM as adjuvant therapy with western conventional medical therapy in the treatment of Wilson’ s disease.A total of 687 participants were included in nine eligible studies. The main ndings are that CHM as monotherapy or adjuvant therapy for Wilson’ s disease may be able to improve the clinical symptoms,to promote the urinary copper excretion,to ameliorate liver function and/or liver cirrhosis,and has fewer adverse effects in comparison with western conventional ***,CHM generally appeared to be safe and well tolerated in patients with Wilson’ s ***,the evidence presented in this review are insuf cient to warrant a clinical recommendation due to the generally low methodological quality of the included *** conclusion,CHM seems to be bene cial and safe for Wilson’ s disease,but high-quality evidence are still needed to further evaluate this ***,additional well-designed, randomized,placebo-controlled clinical trials are needed.