Effect of Rosemary on Oxidative Damage Induced by D-galactose in Senile Mice

作     者：Zesheng ZHANG1,2, Di CHEN1, 2, Hao WANG1, 2 (1.Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin University of Science & Technology, Tianjin, 300457, China 2.Department of Food Engineering and Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China) 

会议名称：《第十三届中国科协年会第3分会场-“食品营养与健康”国际研讨会》

会议日期：2011年

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

关 键 词：Rosemary Open field D-galactose Antioxidant activity 

摘      要：Rodent chronically injected with D-galactose has been used as an animal aging model for brain aging or anti-aging pharmacology research. Rosemary, A large number of compounds within the lipid fraction of rosemary have anti-oxidant ability. In the present study, mice were subcutaneously injected with D-galactose (2%, 7.5ml/kg body weight) for 6 weeks and According to the stated requirement formula mix mice food,To which adding different doses of rosemary (0.05%, 0.15%, 0.3%) drug give treatment *** behavior was observed in the open field at the next day after the last treat-ment six ***-fed mice showed higher activity upon induction by new environmental stimuli,lower anxiety and higher novelty-seeking behavior in the open field *** significantly increased SOD,T-AOC,and CAT activity and decreased the MDA level in serum .These results imply that Rosemary can reverse oxidant impairment induced by D-gal in mice and improve the antioxidant enzymes activity,scavenging free radicals and reduce lipid peroxidation generated and anti-aging,and having a certain function of delaying senility.