Effects of Leonotis leonorus aqueous extract on the isolated perfused rat heart.
作者单位：Department of Pharmacology University of the Western Cape Cape Town （South Africa）. Department of Pharmacology University of the Western Cape Cape Town （South Africa）. Department of Medical Biosciences University of the Western Cape Cape Town （South Africa）. Department of Medical Biosciences University of the Western Cape Cape Town （South Africa）.
会议名称：《第十五届国际药理学大会》
会议日期：2006年
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
关 键 词：Leonotis leonuras isolated perfused heart
摘 要：正 The aim was to determine the effect of Leonotis leonurus （LL） aqueous extract on the isolated perfused rat heart. ADR （1μM） significantly （p0.05） increased the LVSP by 40.6±2.67mmHg, the LVDP by 43.90±3.49mmHg and the HR by 22.49±5.58beats. DIG （2.5 ng/ml）, significantly （p0.05） increased the LVSD by 9.46± 5.04 mmHg. the LVDP by 9.65 ± 5.11mmHg and the HR by22.49±5.58bpm. LL （1.0mg/ml and 2.0mg/ml respectively） significantly （p0.05） increased the LVSP by 25. 36± 8.10mmHg, and 14.91±7.18mmHg. the LVDP by 29.40±2.11mmHg and 14.88±2.11mmHg. L.L. also decreased the HR by 34.73 ±3.70bpm and 42.71±8.02mmHg respectively. ADR effects reflect its positive inotropic and chronotropic effects. Digoxin shows a weaker positive inotropic effect and has little effect on the HR. At low concentrations LL produced a positive inotropic effect and a negative chronotropic effect. At higher concentrations （2.0mg/ ml） LL dropped the values of all parameters to zero. It appears that at this concentration it contains constituents with toxic effects on the heart.