STRUCTURAL STUDY OF TRIAZOLE ANTIFUNGALS
作者单位：Analytical and Metabolic Research LaboratoriesSankyo Co.Ltd.TokyoJapan Medicinal Chemistry Research LaboratoriesSankyo Co.Ltd.TokyoJapan
会议名称：《Sixteenth Congress of the International Union of Crystallography》
会议日期：1000年
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
摘 要：New triazolylmethyl-oxazolidine and-amidoalcohol derivatives were designed and synthesized as potential inhibitors against fungal cytochrome P-450 14α-*** them,(4R,5R)-5- (2,4-difluorophenyl)-4-methyl-5-[(1H-1,2,4-triazol-1-yl)methyl]-3- [4-(trifluoromethyl)benzoyl]oxazolidine shows excellent antifungal activity,in contrast to poor activity for the(4S,5R)-diastereoisomer. And(2R,3R)-2-(4-chlorophenyl)-1-(1H-1,2,4- triazol-1-yl)-3-[[4-(trifluoromethyl)benzoyl]a mino]-2-butanol also has ootent *** crystallographic studies of these three