Highly Efficient Diastereoselective Synthesis of Tetrahydro-isoquinoline-3-carboxylate Ester Analogs from L-DOPA

作     者：WANG, Ye LIU, Zhan-Zhu CHEN, Shi-Zhi LIANG, Xiao-Tian (Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences , Beijing 100050) 

会议名称：《第三届全国有机化学学术会议》

会议日期：2004年

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

摘      要：正 Tetrahydroisoquinoline-3-carboxylate esters are an important motif of naturally occurring bioactive alkaloids and pharmacophores. They are generally regarded as neurotoxic compounds and are putatively involved in a variety of pathologic conditions of central nervous system, including alcoholism, phenylketonuria, and neurodegenerative disorders such as Parkinson’s *** our strategy of the synthesis of the anticancer marine alkaloid Ecteinascidin, tetrahydroisoquinoline-3-car-