Synthesis and Anti-HIV Activity of 2’,3’ -Dideoxyguanosine Analogues

作     者：Zhen-Jun Yang~*,Lu-Jia Xie,Xian-Tao Yang,De-Lin Pan,Xin-Meng Fan,Wu-Jie Li,Zhu Guan,Xiao-Mei Ling State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences, Peking University,Beijing 100191,China 

会议名称：《2011年全国药物化学学术会议——药物的源头创新》

会议日期：2011年

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100701[医学-药物化学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：financially supported by NSFC(200832008) 

摘      要：正Nucleoside drugs play a central role in virus infection *** of ddN and D4N compound（N:nucleoside） were found to be potent anti-viral agents such as clinical drugs Zaicitabine（ddC） and Stavudine（D4T）,*** and D4G did not show good antiviral activity due to their insolubility or instability in *** prodrug approach has been proved successful