Isoflurane preconditioning induces neuroprotection by attenuating ubiquitin-conjugated protein aggregation after transient global cerebral ischemia in mouse

作     者：Hao-Peng ZHANG,Hai-Long DONG*,Su-Bin XIAO~1,Rui MA,Li-Ze Xiong~* Department of Anesthesiology,Xijing Hospital,Fourth Military Medical University,Xi’an 710032,China 

会议名称：《中国神经科学学会第四次会员代表大会暨第八届全国学术会议》

会议日期：2009年

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

关 键 词：Ubiquitin-Proteasome isoflurane preconditioning C57BL/6 mouse global cerebral ischemia 

摘      要：Objective The aim of this study is to clarify the role of ubiquitin-conjugated protein aggregation in the formation of neuroprotective effect of isoflurane preconditioning on the transient global cerebral ischemia-reperfusion injury in the C57BL/6 *** All animals were randomly assigned to two groups(isoflurane preconditioning group and control group,n=36 in each).Mice in isoflurane preconditioning(IP) group were placed in a chamber and pretreated with isoflurane(1.2%isoflurane,98%O