TNF-α mediates hyperalgesia and allodynia by upregulating p-NR1 expression in spinal cord in rats
会议名称：《中国神经科学学会第九届全国学术会议暨第五次会员代表大会》
会议日期：2011年
学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学]
关 键 词：TNF-α p-NR1 hyperalgesia allodynia spinal cord
摘 要：正Objective Following the input of peripheral nociceptive information,some proinflammatory cytokines from microglia,such as TNF-α,will be released,and further produce and maintain the hyperalgesia and allodynia. However,its mechanism is not yet *** is a necessary subunit of NMDAR,and it’s well known that phosphorylation of NRl（p-NRl） can upregulate the plasticity of synaptic transmission,which is the essentials of hyperalgesia and *** consequence,the present study was undertaken to determine whether TNF-αcan mediate hyperalgesia and allodynia by upregulating spinal p-NRl expression in *** The paw withdrawal latency（PWL） test for assessing hyperalgesia / allodynia and Western blot for measuring p-NRl were implemented in the models of CFA-induced peripheral inflammation hyperalgesia or in the rats of TNF-αagonist intrathecally ***（1） Thermalgia responses and spinal p-NRl expression will be upregulated in the models of CFA-induced peripheral inflammation pain,which can be alleviated by TNF-αantagonist;（2） Intrathecal administration of TNF receptor（TNFR1） agonist will induce the development of hyperalgesia / allodynia,and enhance the expression of p-NRl in normal rats,which also can be prevented by TNF-α*** TNF-αmediates hyperalgesia and allodynia by upregulating p-NRl expression in spinal cord in rats.