Hydrogen Gas Ameliorates Oxidative Stress in Early Brain Injury after Subarachnoid Hemorrhage in Rats

作     者：Yan Zhan1,2,MD Chunhua Chen1,MD,PhD Hidenori Suzuki1,MD,PhD Qin Hu1,MD,PhD Xinggang Zhi2,MD John H.Zhang1,MD,PhD 1Department of Physiology and Pharmacology,Loma Linda University,Loma Linda,USA 2Department of Neurosurgery,the First Affiliated Hospital,Chongqing Medical University,Chongqing,China 

会议名称：《第二届西部神经外科学术会议》

会议日期：2010年

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

摘      要：Background and Purpose:Early brain injury is one of the key responsible factors for the poor prognosis of subarachnoid hemorrhage（SAH）.This study was aimed to determine the therapeutic effect of hydrogen gas（H2） inhalation on the early brain ***:SAH was induced by endovascular perforation in male Sprague-Dawley rats,which were divided into three groups:sham,SAH,and SAH treated with 2.9% H2 inhaled for 2 hours after *** 24 and 72 hours after SAH,mortality,body weight,neurologic deficits,and brain water content were ***-brain barrier（BBB） permeability,apoptosis,and oxidative stress were also measured at 24 hours after ***:Hydrogen gas significantly alleviated brain edema and BBB disruption,reduced apoptosis,ameliorated lipid peroxidation and DNA injury,and improved neurological function at 24 hours but not 72 hours after ***:The neuroprotective effect of hydrogen gas may be mediated by anti-oxidative stress during early brain injury after SAH.