解淀粉芽孢杆菌对小鼠肠道健康和免疫功能的影响
作者单位：浙江大学动物科学学院饲料研究所动物营养与饲料科学重点实验室
会议名称：《中国畜牧兽医学会动物微生态学分会第十一次全国学术研讨会暨第五届会员代表大会》
会议日期：2014年
学科分类：090502[农学-动物营养与饲料科学] 0905[农学-畜牧学] 09[农学]
基 金：863项目(2013AA102803D) 浙江省自然科学基金(LY13C170003)~~
关 键 词：Bacillus amyloliquefaciens bacterial enzyme activities intestinal immune cellular immune phagocytes spleen lymphocyte subsets
摘 要：The present study investigated the effects of dietary supplementation of Bacillus amyloliquefaciens SC06 on intestinal environment as well as intestinal,humoral and cellular response in BALB/c *** results showed that dietary Bacillus amyloliquefaciens SC06 could improve intestinal health through affecting bacterial enzyme activities in the caecal and small intestinal *** addition,this Bacillus strain could significantly increase the level of cytokines,β-defensins and the activities of myeloperoxidase(MPO)and secretory phospholipase A2(sPLA2)(P0.05).Oral administration of Bacillus amyloliquefaciens SC06 could significantly increase serum antibody titers and the number of plaque-forming cells.(PFC)(p0.01).For the system immunity response,Bacillus strain SC06 could significantly increase respiratory burst activity of blood phagocytes,the phagocytic function of the mononuclear phagocyte system(MPS),NK cell-mediated cytotoxicity,the percentage of IFN-γ-producing CD4 and CD8 T cells(P0.01),the percentages of CD3 and CD4cell(P0.05).However,it had no effect on lymphocyte proliferation induced by T cell mitogen and B cell *** above,our results indicated that dietary Bacillus amyloliquefaciens SC06 could improve intestinal health through improving microbita composition,and showed positive effect on intestinal,the humoral and the cellular immune function by activating the Th1-type immune response.