Counter current chromatography numerical simulation
会议名称：《第十届全国计算(机)化学学术会议》
会议日期：2009年
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 0703[理学-化学]
基 金：科技部国际合作项目基金(批准号:2007DFA40680) 国家自然科学基金(批准号:20875104)
关 键 词：numerical model retention volume row-stage ratio negative binomial multi-feed stage efficiency
摘 要：For measuring a certain solute’s concentration distribution in counter current chromatography tube,a numerical model was suggested for calculation of the retention volume (V) and simulation of ***-Stage ratio(RSR) was introduced to describe retention time;it has positive proportion to the retention time(RSR =(F/V)t,where F is the flow rate;V is the balance mobile phase volume;t is time.).RSR(RSR =[(1-S+ kS)/(1 - S)](1 -1/n), where S is the retention ratio of stationary phase,n is stages number.) is a constant for a specified k value for a large number of stages(k value is defined as the proportion of concentration in the stationary phase and mobile phase).For a certain material,the concentration distribution is a Negative Binomial(x= Cpqx,where x is the concentration for a solute which distribution ratio is k,x is the initial concentration,p=(1-S)/(1-S+kS), q = kS/(1-S+kS)).For some solvent system,the consumed time for the balance of the solvents is very long and the consumption of solvents is costly,solvents reuse became very important,especially for the balanced ***-feed is essential for such a time and money consumed *** numerical model can predict the optimal feed *** influence to the process for the amount of a feeding solute is discussed *** efficiency(E),which was defined as E = n/n(n is stages,which can be measured by the equation n=1/2πqX,where X is the dimensionless concentration.),was introduced to determine the effect to the spectrum by different k values of different components.