Enantioselective palladium-catalyzed allylic alkylation of indoles by a new class of chiral biquinolyl biphosphine ligand
作者单位：School of Chemistry and Chemical Engineering Guangzhou University
会议名称：《中国化学会第九届全国有机化学学术会议》
会议日期：2015年
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
关 键 词：chiral biphosphine ligands palladium asymmetric allylic allylation
摘 要：A newly developed class of quinoline-based chiral biphosphine ligand, 6,6’-bis（diphenylphosphino）-5,5’- biquinoline（BIQAP） was synthesized via a simple two-step reactions using optically pure BIQOL as starting material and the stereochemical structure of（R）-BIQAP was determined by X-ray crystallography. The chiral BIQAP ligand was successfully applied in Pd-catalyzed asymmetric allylic alkylation of indoles and afforded the desired product in good yields and high enantioselectivities（up to 96% ee）.