The possible mechanisms of SARS corona virus associated lymphopenia and thrombocytopenia
作者单位：Department of Paediatrics The Chinese University of Hong Kong. Department of Microbiology The Chinese University of Hong Kong. Department of Paediatrics The Chinese University of Hong Kong. Department of Anatomical and Cellular Pathology The Chinese University of Hong Kong. Department of Paediatrics The Chinese University of Hong Kong. Department of Paediatrics The Chinese University of Hong Kong. Department of Paediatrics The Chinese University of Hong Kong.
会议名称：《第九届全国实验血液学会议》
会议日期：2003年
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学]
摘 要：正 Severe Acute Respiratory Syndrome （SANS） has been recognised as a new human infectious disease. Anovel coronavirus was identified as the causative agent of SARS. Hematological findings in patients withSARS were common and included lymphopenia （69.6% in adults, N=138;100% in children, N=10）,thrombocytopenia （44.8% in adults. 50% in children） and leukopenia （33.9% in adults, 70% in children） （Leeet al. N Engl J Med. 2003;Hon et al. Lancet. 2003）. The role and mechanism of this coronavirus onhematopoiesis are poorly understood. We hypothesized that SARS coronavirus （SARS-CoV） may （i） directlyinfect blood cells via CD13 or CD66a. thus inducing cell apoptosis and growth inhibition;and/or（ii） induceauto-antibodies and immune complexes to damage these cells. In addition, the lung damage in SARS patients