Could colorimetric method replace the individual minimal erythemal dose(MED) measurements in determining the initial dose of narrow-band UVB treatment?
作者单位：Department of DermatologyHallym University Sacred Heart HospitalAnyangKorea Department of DermatologySeoul National University College of MedicineSeoulKorea
会议名称：《The Second Eastern Asia Dermatology Congress(EADC2012)》
会议日期：2012年
学科分类：1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学]
摘 要：Background Assessment of minimal erythemal dose(MED) for individual patients has been used to guide the narrow- band UVB(NB-UVB) phototherapy,which sometimes causes discomfort and additional *** L value(the lightness of color in Commission Internationlale de l’Eclairge Lab color scale) measured by colorimeter was shown to be useful for predicting sensitivity to NB-UVB *** aim of the study was to compare the efficacy and safety of NB-UVB phototherapy between 50%of MED and colorimetric L value starting dose regimens for skin phototype III to V Korean patients with psoriasis. Method Twenty seven patients determined starting doses based on colorimetric L value,and 27 patients based on 50% of *** correlation analysis showed that L value had the most significant association with MED compared with skin phototypes,a,and b values,we designated starting doses of L value regimen as follows:300 mJ/cm(L 66), 400 mJ/cm(62 L 66),and 500 mJ/cm(L 62). Results There was no significant difference between two groups in clinical efficacy including response rate,mean number of sessions,duration of treatment,maximum dose,and cumulative dose until achieving the state of near *** proportion of adverse effects was not also significantly different. Conclusions NB-UVB starting dose determination based on colorimetric L value was comparable with conventional MED based regimen in efficacy and safety for skin phototype III-V *** it provides much convenience and ease for both patients and physicians,colorimetric L value could partly substitute the MED checking methods in NB-UVB phototherapy.