The spinal circuitry:a functional unit of the brain for motor control
会议名称：《中国神经科学学会第四次会员代表大会暨第八届全国学术会议》
会议日期：2009年
学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学]
关 键 词：motor cortex spinal circuits reflexes sensorimotor system muscles spindles GTOs biomechanics motor control
摘 要：正The spinal motoneurons（MNs） extend a connection between the motor cortex in the brain and the peripheral neuromuscular apparatus that executes *** is perplexing to find a complex circuitry existed in the spinal cord interweaving the MNs via spinal interneurons（IN）.The extensive convergence of proprioceptive afferents to the interneuronal networks suggests important roles that may be played by these ***,it is disappointing that the functional use of these circuits in motor control has not been clear,even though their neuronal links have long been *** this report,we introduce a computational approach aimed at revealing the functional role of spinal circuits in motor *** approach relies on an integrative,multi-scale modeling of the musculoskeletal and sensorimotor system with realistic neural physiological *** motor behaviors of the regulated system can be simulated with various scenarios of reflex configurations and feedback *** results indicated that the nonlinear biomechanical and physiological properties of the musculoskeletal system play a significant constraint to the ability to achieve a wide range of equilibrium position from an initial position with low feedback gains.A movement command is necessary to transfer the arm from one region associated to a particular initial position to another,and an adaptive strategy may be programmed to facilitate gain scheduling associated to a particular *** is consistent with recent experimental findings that suggest separate control of movement and position by the *** is promising that a computational approach combined with experimental probing is emerging to provide new insights into the spinal mechanism of motor control.