Essential role of PKC-delta in radial migration of cortical neurons
会议名称：《中国神经科学学会第四次会员代表大会暨第七届全国学术会议》
会议日期：2007年
学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学]
关 键 词：radial migration cortex PKC-delta P35 TrkB
摘 要：正The layered structure of the mammalian neocortex is formed through a well-coordinated radial migration of cohorts of post-mitotic neurons during early *** proteins have been identified as essential for the migration of neurons and the formation of stereotyped cortical ***,how the newborn neurons are regulated to migrate or to terminate their migration at their destined layers remains *** we examined the contribution of a member of novel PKC in the migration of newborn neurons to their final layer in developing rat cortex. Using in utero electroporation of small interference RNAs（siRNA）,we found that specific down-regulation of PKC-delta severely impaired the targeting of the newborn neurons to their destined layers,without affecting proliferation of neural progenitor cells or the differentiation of newborn *** also found that down-regulation of cdk5 lead to similar migration defect to that of *** antibody against p35 immunoprecipitated ***,brain- neurotrophic factor（BDNF） strongly increased the phosphorylation level of both PKC-delta and *** of TrkB receptor also lead to migration defects of cortical ***,the PKC-delta signaling may interact with p35-cdk5 complex and regulate the proper radial migration of newborn cortical neurons.