NMR Studies on the Interactions between Proteins and Antigen Peptides in MHC Class I Protein Complex of Immune System
作者单位：Biological Information Research CenterNational Institute of Advanced Science and IndustryTsukuba Central 61-1HigashiTsukubaIbaraki 305-8566Japan
会议名称：《第十三届全国波谱学学术会议》
会议日期：2004年
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学]
关 键 词：NMR interaction between peptide and protein MHC Class I protein Antigen peptides line broadening Transfer-NOE 15N and D enriched protein β2-microglobulin
摘 要：正A major histocompatibility complex（MHC）class Ⅰ protein consists of heavy chain which has α-1,2,3 domains and light chain（β2,microgiobulin,β2 m）.An antigen peptide binds to a peptide binding groove in the α1 andα2 domains of MHC class Ⅰ *** class Ⅰ protein traps a foreign peptide inside a cell