Expression of the monocarboxylate transporter MCT1,MCT2 and MCT4 in the developing rat brain
会议名称：《中国神经科学学会第四次会员代表大会暨第八届全国学术会议》
会议日期：2009年
学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学]
关 键 词：monocarboxylate MCT1 MCT2 MCT4
摘 要：正Monocarboxylate transporters（MCTs） play an important role in brain energy *** mediate the transport of monocarboxylates,such as lactate and pyruvate and ketone bodies,which represent a major source of energy for the brain,particularly during *** the expressions of MCT1,MCT2 and MCT4 in the brain of the rat were studied during postnatal *** report each of these isoforms exhibited regional and cellular distribution in the *** of them were found in most brain areas,including cortex,hippocampus,striatum,substantia nigra and cerebellum, from birth to *** the cellular level,the MCT1 was expressed by endothelial cells of blood vessels,ependymocytes, and *** MCT4 expression seemed to be restricted to *** contrast,the MCT2 was only found in *** MCT1 and MCT2 were most abundant in the first 3 postnatal weeks and thereafter decreased toward *** MCT4 expression was very low at birth but was enhanced strongly at postnatal day 14,reaching adult *** changes in expression of these MCTs throughout the postnatal period suggest that they may have a potential relation with the maturation of the blood-brain barrier and the gradual switch from a prominent use of blood-borne monocarboxylates to glucose utilization by the brain.