Androgen activates PEG10 to promote carcinogenesis in hepatic cancer cells Running title: Hepatocarcinogenesis and PEG10 activation

作     者：Xiong Jie, Li Chaoqun, Yang Dehua, Shi Yi, Hu Chunsong, Gong Feili, Jin Boquan, Jin Youxin, Tan Jinquan (Department of Immunology, and Laboratory of Allergy and Clinical Immunology, Institute of Allergy and Immune-related Diseases and Medical Research Center, Wuhan University School of Medicine, Wuhan, 430071 The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai, 200031 Department of Infectious Diseases, Ruijin Hospital, Shanghai Second Medical University. Shanghai, 200025 College of Life Sciences, South China Normal University, Guangzhou, 510631 Department of Immunology, College of Basic Medical Sciences, Anhui Medical University, Hefei 230032 Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan Department of Immunology, Fourth Military Medical University, Xian, P. R. China 

会议名称：《中国免疫学会第五届全国代表大会暨学术会议》

会议日期：2006年

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

摘      要：The molecular mechanisms of hepatocellular carcinoma (HCC) with a striking higher prevalence in male remain to be fully elucidated. We here report the differentially expression of androgen receptor (AR) in different HCC cells and normal hepatocytes. AR agonist dihydrotestosterone (DHT) can promote HCC cell growth and apop-totic resistance, whereas AR antagonist can significantly block the effects of DHT on the HCC cells. Paternally Ex-