一种抗尿激酶受体抗体的晶体结构及其抗原结合位点分析
作者单位：State Key Laboratory of Structural ChemistryFujian Institute of Research on the Structure of MatterThe Graduate School of Chinese Academy of SciencesChinese Academy of Sciences State Key Laboratory of Structural ChemistryFujian Institute of Research on the Structure of MatterThe Graduate School of Chinese Academy of SciencesChinese Academy of Sciences Attenuon L.L.C.10130 Sorrento Valley RoadSuite BSan DiegoCA 92121USA Laboratory for Structural BiologyDepartment of ChemistryGraduate Programs of BiotechnologyChemistry and Materials ScienceUniversity of Alabama in HuntsvilleHuntsvilleAlabama 35899USA. Attenuon L.L.C.10130 Sorrento Valley RoadSuite BSan DiegoCA 92121USA Attenuon L.L.C.10130 Sorrento Valley RoadSuite BSan DiegoCA 92121USA State Key Laboratory of Structural ChemistryFujian Institute of Research on the Structure of MatterThe Graduate School of Chinese Academy of SciencesChinese Academy of Sciences
会议名称：《第十次中国生物物理学术大会》
会议日期：2006年
学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种]
摘 要：正尿激酶受体（urokinase receptor,uPAR）又称CD-87,是一种糖基化的表面膜蛋白,以其C末端糖基化磷脂酰肌醇（GPI）锚定在膜上。它能够表达于包括白细胞、内皮细胞、血管光滑细胞、成纤维细胞、滋养层细胞及各种肿瘤细胞的表面。尿激酶受体能够和包括尿激酶（纤溶酶原的主要激活物之一）在内的多种细胞外的分子相互作用,