Comparative analysis of protein linkages in Bordetella brochiseptica,Bordetella parapertussis and Bordetella pertussis

作     者：Yongzhang Zhu, Qingtian Li, Jiayou Chu, Jingchun sun, guohui ding ,guang li, Tieliu shi, Xiaokui Guo Institute of Medical Biology, Peking Union Medical College & Chinese Academy of Medical Sciences, Kunming 650118, China Department of Medical Microbiology and Parasitology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China Bioinformation Center, Shanghai Institute for Biological Science, Chinese Academy of Science, Shanghai 200031 

会议名称：《首届全国微生物基因组学学术研讨会》

会议日期：2006年

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

摘      要：Despite widespread vaccine coverage, the incidence of whooping cough (pertussis) , has again risen recently. The causative agents, Bordetella brochiseptica, Bordetella parapertussis and Bordetella pertussis, are closely related gram-negative pathogen. B. pertussis is exclusively human-adapted and is the primary etiologic agent of acute childhood respiratory whooping cough;B. parapertussis has been only associated with similar respiratory infection in human and sheep;B. brochiseptica infects a wide range of mammalian host, including rat, rabbit, dog and human, and typically causes chronic, asymptomatic infections.