Regulation of integrated and covalently closed circular form of Hepatitis B virus (HBV) replication by cytokines
作者单位：National Health Research Institutes ZhunanMiaoliTaiwan
会议名称：《第五届海峡两岸细胞生物学学术研讨会》
会议日期：2005年
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学]
摘 要：Chronic hepatitis B (CHB) is one of the most serious viral infections worldwide, which is also a high risk factor for cirrhosis and hepatocellular carcinoma (HCC). Several studies have reported that yirus persistence in CHB patients relies on maintaining a pool of viral covalently closed circular DNA (cccDNA) in the nuclei of infected hepatocytes, which presumably served as the template for HBV gene expression and viral replication. Apparently, cccDNA may play a pivotal role in the life cycle of HBV replication and may be responsible