Atrial-selective Inhibition of Sodium Channel Current by Wenxin Keli is Effective in Suppressing Atrial Fibrillation
作者单位：Masonic Medical Research Laboratory
会议名称：《2014中国医师协会中西医结合医师大会》
会议日期：2014年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
关 键 词：Antiarrhythmic drugs atrial fibrillation arrhythmias electrophysiology pharmacology
摘 要：Background—Wenxin Keli is a Chinese herb extract reported to be of benefit in the treatment of cardiac arrhythmias,cardiac inflammation and heart *** and Results—We evaluated the electrophysiologic effects of Wenxin Keli in isolated canine arterially-perfused right atrial preparations with a rim of right ventricular tissue(n = ll).Transmembrane action potentials and a pseudo-electrocardiogram were simultaneously ***(ACh,1 μM) was used to induce atrial fibrillation(AF) and to test the anti-AF potential of Wenxin Keli(5 g/L).Wenxin Keli produced preferential abbreviation of action potential duration(APD90) in atria,but caused atrial-selective prolongation of effective refractory period,due to development of post-repolarization *** maximum rate of rise of the action potential upstroke(Vmax)was preferentially reduced in *** threshold of excitation increased in both atria and ventricles,but much more in *** duration of the P wave(index of atrial conduction time)was prolonged to a much greater extent than the duration of the QRS complex(index of ventricular conduction time).Wenxin Keli significantly reduced INa and shifted steady-state inactivation to more negative potentials in HEK293 cells stably expressing SCN5 *** Keli prevented induction of persistent AF in 100%atria(6/6)and,in another experimental series was found to terminate persistent ACh-mediated AF in 100%of atria(3/3).Conclusions—Wenxin Keli produces atrial-selective depression of INa-dependent parameters in canine isolated coronary perfused preparations via a unique mechanism and is effective in suppressing AF and preventing its induction,with minimal effects on ventricular electrophysiology.