Function and Inhibition of Prolyl Dipeptidases
会议名称：《第五届海峡两岸细胞生物学学术研讨会》
会议日期：2005年
学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学]
摘 要：Prolyl dipeptidase family contains DPP-Ⅳ, FAP, DPP8, DPP9 and DPP-Ⅱ.They cleave specifically at the peptide bond of the penultimate proline residue. These proteases play important roles in vivo: DPP-Ⅳ is a drug target for type Ⅱ diabetes, and FAP is the cancer marker for the epithelial cancer types. We are interested in (1) understanding the