A novel sensitive and selective real-time cellular assay for detection of endocrine disruptors using native endocrine signaling pathways
作者单位：艾森生物(杭州)有限公司
会议名称：《生命的分子机器及其调控网络——2012年全国生物化学与分子生物学学术大会》
会议日期：2012年
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100101[医学-人体解剖与组织胚胎学] 10[医学]
摘 要：A cell based assay for detection of endocrine disrupters has been previously developed us-ing real time impedance monitoring of native endocrine signaling pathways in T47D breast cancer cell *** of T47D cells with respective endocrine hormones (*** or progesterone) leads to distinct time dependent cellular changes(cell number change and/or cell morphological change) which can be detected by gold microelectrodes embedded in the bottom of the well of specialized microelectronic plates