Intrauterine hyperglycemia altered both imprinting erasure and reestablishment process in germ cells of male offspring
作者单位：Department of PathophysiologyZhejiang University The International Peace Maternnity And Child Health HospitalSchool of MedicineShanghai jiaotong University The Key Laboratory of Reproductive GeneticsMinistry of EducationChina
会议名称：《中国中西医结合学会生殖医学分会首届学术年会暨生殖医学专业委员会成立大会》
会议日期：2014年
学科分类：0710[理学-生物学] 07[理学] 071008[理学-发育生物学]
摘 要：OBJECTIVE:It has been reported the expression of some imprinted genes were significantly altered in gestational diabetes mellitus(GDM)*** imprinting erasure occurred during E11.5-13.5,while imprinting reestablishrnent is completed at E18.5 in male mice *** function of methyltransferases 1(DNMT1)is maintaining methylation,and DNMT3a/3b are