Quantitative analysis of virulent duck enteritis virus loads in experimentally infected duckings

作     者：Yang Xiaoyan Cheng Anchun Wang Mingshu Qi Xuefeng Guo Yufei Jia Renyong (Research Center of Avian Disease,College of Animal Science and Veterinary Medicine of Sichuan Agricultural University,Ya’an,Sichuan,625014,China.Key Laboratory of Animal Disease and Human Health of Sichuan Province,Ya’an,Sichuan,625014,China.College of Life Science and Chemistr of Dali University,Da’li,Yunnan,671000,China) 

会议名称：《第四届第九次全国学术研讨会暨饲料和动物源食品安全战略论坛》

会议日期：2008年

学科分类：090603[农学-临床兽医学] 09[农学] 0906[农学-兽医学] 

关 键 词：Duck enteritis virus Quantitation Pathogenesis 

摘      要：To understand better the pathogenesis of duck virus enteritis (DVE),the levels of viral DNA in various tissues of duckling during acute stage of virulent duck enteritis virus (DEV) infection were investigated by using quantitative real-time *** results show that the viral levels of DEV in systemic organs have a close correlation with the progression of *** rapid dissemination of virulent DEV to systemic organs and active replication in lymphoid tissues at the early phase of acute infection accelerate the progression of *** levels of viral DNA increased sharply soon after develop clinical signs of disease,and the extent of increase and the final magnitude of DEV DNA load in various tissues of ducklings immediately following the exhibition of clinical signs may be a critical determinant of the outcome of DEV *** relatively high level of DEV infection and replication in bursa and intestine tissues of dead ducklings most likely reflects the abundance of target epithelial and lymphoid cells in these tissues,and therefore play a key role in the pathogenesis of acute DVE manifested as severe lesions on the lymphoid tissues and small intestine.