Impact of hepatitis B vaccination among children in Guangdong Province,China
作者单位：Guangdong Provincial Center for Disease Control and Prevention
会议日期：2014年
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学]
关 键 词：Prevalence Hepatitis B vaccination Vaccination coverage
摘 要：Objective:To evaluate the impact of the universal infant hepatitis B vaccination program on hepatitis B virus(HBV) infection in Guangdong ***:In 2006,a serosurvey was conducted in Guangdong Province among children aged 15 years,14 years after the introduction of universal infant hepatitis B *** participants were selected by stratified,multi-stage random *** characteristics and hepatitis B vaccination history were collected by a questionnaire and a review of the vaccination records,and serum specimens were tested for hepatitis B surface antigen(HBsAg),antibody to hepatitis B core antigen(anti-HBc),and antibody to hepatitis B surface antigen(anti-HBs) by EL1 *** prevalence rate of HBV serological markers and the rate of immunization coverage in this survey were compared with those of the 1992 and2002 ***:A total of 1967 children aged 15 years participated in *** prevalence rate of HBsAg decreased from 19.86%in the 1992 survey to 4.91%in the 2006 *** rates of three-dose and timely birth dose coverage of hepatitis B vaccine were 92.40%and 70.84%,respectively,among children born during the period *** prevalence of HBsAg was significantly lower among fully immunized children(1.99%) than among unvaccinated children(5.56%).Condusions:Guangdong Province has successfully integrated the hepatitis B vaccine into routine immunization programs and this has had a very significant impact on decreasing the HBsAg carrier rate among children.